4-broMo-N1-Methylbenzene-1,2-diaMine synthesis
- Product Name:4-broMo-N1-Methylbenzene-1,2-diaMine
- CAS Number:69038-76-2
- Molecular formula:C7H9BrN2
- Molecular Weight:201.06
53484-26-7
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69038-76-2
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$28.00/100mg
Yield: 99%
Reaction Conditions:
with iron;ammonium chloride in methanol at 80; for 4 h;
Steps:
To a solution of 4-bromo-N-methyl-2-nitroaniline (2.1 g, 9 mmol) in MeOH (50mL) was added Fe powder (2.5 g, 45 mmol) and NH4C1 (4.8 g, 90 mmol). The mixture wasstirred at 80 °C for 4 h, poured into H20 (60 mL) and extracted with EA (40 mL x 2). The organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford 4-bromo-N’-methylbenzene-1,2-diamine (2.0 g, 99 %) as a yellow solid. LC-MS m/z: 203.1 [M+Hj . tR = 1.64 min
References:
LYSOSOMAL THERAPEUTICS INC.;SKERLJ, Renato, T.;BOURQUE, Elyse Marie Josee;LANSBURY, Peter, T.;GOOD, Andrew, C. WO2017/176960, 2017, A1 Location in patent:Paragraph 00743
364-73-8
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74-89-5
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69038-76-2
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$28.00/100mg
364-73-8
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69038-76-2
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$28.00/100mg
875-51-4
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69038-76-2
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367-86-2
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69038-76-2
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