ChemicalBook CAS DataBase List 4-Bromo-1-fluoro-2-nitrobenzene

4-Bromo-1-fluoro-2-nitrobenzene synthesis

4synthesis methods

Product Name:4-Bromo-1-fluoro-2-nitrobenzene
CAS Number:364-73-8
Molecular formula:C6H3BrFNO2
Molecular Weight:220

1493-27-2

364-73-8

General procedure for the synthesis of 4-bromo-1-fluoro-2-nitrobenzene from 1-fluoro-2-nitrobenzene: After completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into ice water. The product 2-fluoro-5-bromonitrobenzene in the aqueous phase was extracted with 200 mL of ethyl acetate, and the organic phases were combined and concentrated under reduced pressure to give a brown solid crude product. The crude product was purified by recrystallization from petroleum ether and analyzed by gas chromatography (GC) with a purity of 98%, and 227.1 g of the pure product was obtained after drying with a yield of 40.0%.

1493-27-2
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364-73-8
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Yield:364-73-8 97.1%

Reaction Conditions:

with N-Bromosuccinimide;acetic acid at 15;

Steps:

1 (1) Upper bromine reaction:
200 g of o-fluoronitrobenzene and 1000 mL of solvent acetic acid were added to the reaction vessel.The temperature was controlled at about 15 degrees, and 268 g of the bromine reagent N-bromosuccinimide was added in portions.After the addition is completed, stir for a while, GC tracking,Until the reaction is completed. After the reaction is completed, the ice water is hydrolyzed and filtered.Obtained an off-white solid 5-bromo-2-fluoronitrobenzene303 g,97% purity,The yield was 97.1%.

References:

Changzhou University;Chen Xingquan;Dong Yanmin CN109354569, 2019, A Location in patent:Paragraph 0010; 0013

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364-76-1 Synthesis