4-(BROMOMETHYL)-2-FLUOROBENZONITRILE synthesis
- Product Name:4-(BROMOMETHYL)-2-FLUOROBENZONITRILE
- CAS Number:222978-03-2
- Molecular formula:C8H5BrFN
- Molecular Weight:214.03
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Yield: 88.79%
Reaction Conditions:
with N-Bromosuccinimide;dibenzoyl peroxide in chloroform for 12 h;Reflux;
Steps:
1 4-nitrile-3-fluorobenzyl chloride (2)Of the preparation11
3-fluoro-4-nitrile toluene 1 (10 g, 74.07 mmol)Dissolved in chloroform 200mL,Add BPO 1g, stirring dissolved,NBS (19.77 g, 11.11 mmol) was added portionwise,Reflux 12h,Cooling, the reaction solution with saturated aqueous solution of sodium bicarbonate 3 times wash,Wash the amount of water 3 times, the amount of saturated salt water washed 3 times, evaporation of the solvent under reduced pressure, column chromatography was pale yellow liquid 14.00g, yield88.79%.
References:
China Pharmaceutical University;Li Zhiyu;Bian Jinlei;Xu Xi;Ge Raoling CN106810552, 2017, A Location in patent:Paragraph 0068; 0070; 0071
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