4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl synthesis
- Product Name:4-(bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl
- CAS Number:613241-14-8
- Molecular formula:C14H10BrF3
- Molecular Weight:315.13
457889-46-2
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Yield:613241-14-8 65%
Reaction Conditions:
with phosphorus tribromide in diethyl ether;dichloromethane at 0; for 2 h;
Steps:
107.B
Step B. 4'-Bromomethyl-4-trifluoromethyl-biphenyl; Phosphorous tribromide (8.67mmol, 1.OM in dichloromethane) is added to a stirred solution of 4'-trifluoromethyl-biphenyl-4-yl)-methanol (2.08g, 8.25mmol) in ethyl ether (40mL) at 0° C under inert atmosphere of nitrogen. The reaction is stirred at 0° C for two hours, quenched at 0° C with water, diluted mixture with ethyl acetate, washed with water, then brine. Organics are dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue is purified by column (silica gel) in 0-40% ethyl acetate/hexane gradient to give 1.68g (5.33mmol, 65%) of title compound.
References:
WO2005/118542,2005,A1 Location in patent:Page/Page column 119
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