4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE synthesis
- Product Name:4-CHLORO-1-H-IMIDAZO[4,5-C]PYRIDINE
- CAS Number:2770-01-6
- Molecular formula:C6H4ClN3
- Molecular Weight:153.57
39217-08-8
198 suppliers
$18.00/1g
149-73-5
547 suppliers
$12.00/5g
2770-01-6
134 suppliers
$19.00/250mg
Yield:2770-01-6 98%
Reaction Conditions:
with hydrogenchloride in water at 20;Inert atmosphere;
Steps:
22.1 Step 1: Preparation of 4-chloro-1H-imidazo[4,5-c]pyridine (intermediate S1-1)
2-chloro-3,4-diaminopyridine (2.87 g, 20 mmol) and trimethyl orthoformate (40 mL) were added into a round-bottom flask, and concentrated hydrochloric acid (3 mL) was slowly added dropwise at room temperature, the mixture solution was stirred overnight at room temperature.
A large number of solids were precipitated and filtered out, and the filter cake was washed with petroleum ether and dried to obtain the crude product of 4-chloro-1H-imidazo[4,5-c]pyridine (3.7 g, yield 98%). MS m/z (ESI): 154 [M+H]+.
References:
Abbisko Therapeutics Co., Ltd.;ZHANG, Mingming;ZHAO, Baowei;YU, Hongping;CHEN, Zhui;XU, Yaochang US2020/140431, 2020, A1 Location in patent:Paragraph 0166; 0211-0213
![3H-IMidazo[4,5-c]pyridine, 5-oxide](/CAS/GIF/91184-02-0.gif)
91184-02-0
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$45.00/2.5mg
2770-01-6
134 suppliers
$19.00/250mg
39217-08-8
198 suppliers
$18.00/1g
14036-06-7
112 suppliers
$56.00/5g
2770-01-6
134 suppliers
$19.00/250mg
19798-80-2
550 suppliers
$6.00/1g
2770-01-6
134 suppliers
$19.00/250mg
39217-08-8
198 suppliers
$18.00/1g
122-51-0
506 suppliers
$10.00/5ml
2770-01-6
134 suppliers
$19.00/250mg