4-Chloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine synthesis
- Product Name:4-Chloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine
- CAS Number:871024-30-5
- Molecular formula:C8H8ClN3
- Molecular Weight:181.62
![4-CHLORO-5H-PYRROLO[3,2-D] PYRIMIDINE](/CAS/GIF/84905-80-6.gif)
Yield:871024-30-5 88%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide;
Steps:
Intermediate 2 4-Chloro-5-ethyl-pyrrolo[3,2-d]pyrimidine
Intermediate 2 4-Chloro-5-ethyl-pyrrolo[3,2-d]pyrimidine To a soiution of 4-chloro-5H-pyrroio[3,2-d]pyrimidine (150mg, 0.98mmol) and caesium carbonate (637mg, 1.96mmol) in DMF (5ml) was added bromoethane (128mg, 1. 8mmo) and stirred overnight. The mixture was diluted with EtOAc and washed with water (x3). The organic phase was separated, dried and concentrated to give a brown solid <156mg, 88%); 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 146 (t, J=7.3 Hz, 3 H), 4.50 (q, J=6.9 Hz, 2 H), 6.66 (d, J=3.2 Hz, 1 H), 7.47 (d, J=3.2 Hz, 1 H), 8.63 (s, 1 H); LC-MS (ESI): (MH+) 182 / 184
References:
WO2017/85483,2017,A1 Location in patent:Page/Page column 36
75-03-6
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