4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL synthesis
- Product Name:4-CHLORO-5-FLUORO-2-PYRIDINEMETHANOL
- CAS Number:113209-90-8
- Molecular formula:C6H5ClFNO
- Molecular Weight:161.56
31181-53-0
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113209-90-8
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: m-chloroperbenzoic acid / CH2Cl2 / 16 h / Ambient temperature
2: 72 percent / HNO3, 30percent oleum, conc. H2SO4 / 1) 5 deg C to RT, 1 h, 2) steam bath, 2 h
3: 89 percent / POCl3 / CH2Cl2 / 1) RT, 16 h, 2) reflux, 4 h
4: 53 percent / trifluoroacetic anhydride / CH2Cl2 / 168 h / Ambient temperature
References:
Ife;Dyke;Keeling;Meenan;Meeson;Parsons;Price;Theobald;Underwood [Journal of Medicinal Chemistry,1989,vol. 32,# 8,p. 1970 - 1977]
113209-89-5
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113209-90-8
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45673-79-8
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108-24-7
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$14.00/250ML
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113209-90-8
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113209-88-4
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$45.00/10mg
113209-90-8
74 suppliers
$130.00/100mg