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135948-75-3

4-CHLORO-6-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDINE synthesis

2synthesis methods
1193-21-1 Synthesis
4,6-Dichloropyrimidine

1193-21-1
570 suppliers
$16.00/5g

4-CHLORO-6-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDINE

135948-75-3
11 suppliers
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Yield:135948-75-3 38%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 20; for 16 h;

References:

King, Dalton;Iwuagwu, Christiana;Cook, Jim;McDonald, Ivar M.;Mate, Robert;Zusi, F. Christopher;Hill, Matthew D.;Fang, Haiquan;Zhao, Rulin;Wang, Bei;Easton, Amy E.;Miller, Regina;Post-Munson, Debra;Knox, Ronald J.;Gallagher, Lizbeth;Westphal, Ryan;Molski, Thaddeus;Fan, Jingsong;Clarke, Wendy;Benitex, Yulia;Lentz, Kimberley A.;Denton, Rex;Morgan, Daniel;Zaczek, Robert;Lodge, Nicholas J.;Bristow, Linda J.;Macor, John E.;Olson, Richard E. [ACS Medicinal Chemistry Letters,2017,vol. 8,# 3,p. 366 - 371] Location in patent:supporting information