4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine synthesis
1synthesis methods
- Product Name:4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine
- CAS Number:1604677-77-1
- Molecular formula:C10H6Cl3N3
- Molecular Weight:274.53
Yield:1604677-77-1 55%
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0);potassium carbonate in 1,4-dioxane;water at 80; for 0.5 h;Inert atmosphere;Sealed tube;
References:
Farand, Julie;Kropf, Jeffrey E.;Blomgren, Peter;Xu, Jianjun;Schmitt, Aaron C.;Newby, Zachary E.;Wang, Ting;Murakami, Eisuke;Barauskas, Ona;Sudhamsu, Jawahar;Feng, Joy Y.;Niedziela-Majka, Anita;Schultz, Brian E.;Schwartz, Karen;Viatchenko-Karpinski, Serge;Kornyeyev, Dmytro;Kashishian, Adam;Fan, Peidong;Chen, Xiaowu;Lansdon, Eric B.;Ports, Michael O.;Currie, Kevin S.;Watkins, William J.;Notte, Gregory T. [ACS Medicinal Chemistry Letters,2020,vol. 11,# 3,p. 358 - 364]