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ChemicalBook CAS DataBase List 4-CHLORO-6-HYDROXYQUINAZOLINE
848438-50-6

4-CHLORO-6-HYDROXYQUINAZOLINE synthesis

6synthesis methods
6-ACETOXY-4-CHLOROQUINAZOLINE

179246-11-8

4-CHLORO-6-HYDROXYQUINAZOLINE

848438-50-6

Step E: Preparation of 4-chloroquinazolin-6-ol: 4-chloroquinazolin-6-yl acetate (10.0 g, 44.9 mmol) was dissolved in a methanol solution of ammonia (200 mL, 7N), and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to about 3 mL, and the residue was ground with ether to precipitate a tan solid which was collected by filtration and dried to give 4-chloroquinazolin-6-ol (6.50 g, 80% yield).

179246-11-8 Synthesis
6-ACETOXY-4-CHLOROQUINAZOLINE

179246-11-8
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Yield:848438-50-6 95%

Reaction Conditions:

with ammonia in methanol at 20; for 3 h;Inert atmosphere;

Steps:

The fourth step: the synthesis of 4-chloroquinazolin-6-ol

Dissolve 4-chloroquinazolin-6-yl acetate (700 mg, 3.144 mmol) in methanol (5 mL), add 7N ammonia methanol solution (15 mL), stir at room temperature for 3 hours, add methyl tert-butyl ether, and precipitate The product was precipitated, filtered, and the filter cake was washed with an appropriate amount of methyl tert-butyl ether, and dried to obtain 4-chloroquinazolin-6-ol (600 mg, yield: 95%).

References:

WO2022/105908,2022,A1 Location in patent:Page/Page column 24; 38

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