4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE synthesis
- Product Name:4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- CAS Number:39065-95-7
- Molecular formula:C7H6ClF2NO
- Molecular Weight:193.58
40750-71-8
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Yield:39065-95-7 64.2%
Reaction Conditions:
with hydrogen in ethyl acetate at 30 - 40; under 15001.5 - 22502.3 Torr; for 1 h;Autoclave;Temperature;Solvent;
Steps:
5 Example 5:
167 g of 4-nitro-chlorodifluoromethoxybenzene was charged into the autoclave followed by 200 g of ethyl acetate and 15 g of Raney nickel. After the replacement of nitrogen and hydrogen, the pressure in the autoclave is kept at about 2~3 MPa with hydrogen and reacted at 30-40 ° C. When the pressure of the system is no longer changing, the reaction is maintained for 1 hour. The sample is analyzed and controlled to be less than 0.5% Hydrogenation reaction liquid filtered catalyst, the first atmospheric pressure recovery of most of the solvent, and then vacuum distillation, the target product 4- (chlorodifluoromethoxy) aniline 92.6g, a yield of 64.2%.
References:
CN104119238,2016,B Location in patent:Paragraph 0018; 0032; 0033; 0037; 0038
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140 suppliers
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