4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- CAS No.
- 39065-95-7
- Chemical Name:
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
- Synonyms
- 4-(CHLORODIFLUOROMETHOXY)ANILINE;EOS-60713;TIMTEC-BB SBB000319;Pinacolborane Impurity 43;4-(Chlorodifluoromethoxy)aniline98%;4-(Chlorodifluoromethoxy)aniline95%;4-(chlorodifluoromethoxy)benzenamine;4-(Chlorodifluoromethoxy)aniline 98%;4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE;Benzenamine, 4-(chlorodifluoromethoxy)-
- CBNumber:
- CB7152805
- Molecular Formula:
- C7H6ClF2NO
- Molecular Weight:
- 193.58
- MDL Number:
- MFCD01820809
- MOL File:
- 39065-95-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Chlorodifluoromethoxyaniline | C366070 | 1g | $165 |
| 4-(Chlorodifluoromethoxy)aniline 96% | 4656-7-X3 | 1g | $199 |
| 4-(Chlorodifluoromethoxy)aniline 96% | 4656-7-X3 | 250mg | $132 |
| 4-(Chlorodifluoromethoxy)benzenamine | 189179 | 500mg | $750 |
| 4-(Chlorodifluoromethoxy)aniline | 1935AQ | 10g | $909.2 |
| Boiling point | 231.9±40.0 °C(Predicted) |
|---|---|
| Density | 1.402±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Chloroform (Slightly), DMSO (Sparingly) |
| form | liquid |
| pka | 4.04±0.10(Predicted) |
| color | Pale yellow |
| InChI | InChI=1S/C7H6ClF2NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2 |
| InChIKey | QDTUQGSYECRXDO-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OC(Cl)(F)F)C=C1 |
| UNSPSC Code | 12352116 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38-43-22 |
| Safety Statements | 26-36/37/39-36/37 |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HS Code | 2921420090 |
| Storage Class | 11 - Combustible Solids |
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C366070 | 4-Chlorodifluoromethoxyaniline | 39065-95-7 | 1g | $165 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4656-7-X3 | 4-(Chlorodifluoromethoxy)aniline 96% | 39065-95-7 | 1g | $199 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4656-7-X3 | 4-(Chlorodifluoromethoxy)aniline 96% | 39065-95-7 | 250mg | $132 | 2021-12-16 | Buy |
| Matrix Scientific | 189179 | 4-(Chlorodifluoromethoxy)benzenamine | 39065-95-7 | 500mg | $750 | 2021-12-16 | Buy |
| AK Scientific | 1935AQ | 4-(Chlorodifluoromethoxy)aniline | 39065-95-7 | 10g | $909.2 | 2021-12-16 | Buy |
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Chemical Properties,Uses,Production
Uses
4-Chlorodifluoromethoxyaniline has been used as a reactant for the preparation of arylphthalazines as a potent and orally bioavailable inhibitor of VEGFR-2.
Synthesis
40750-71-8
39065-95-7
General procedure for the synthesis of 4-(chlorodifluoromethoxy)aniline from 1-(chlorodifluoromethoxy)-4-nitrobenzene: 167 g of 1-(chlorodifluoromethoxy)-4-nitrobenzene was added to an autoclave, followed by the addition of 200 g of ethyl acetate and 15 g of nickel Nguyenne. After changing to a nitrogen atmosphere, hydrogen was introduced and the pressure in the autoclave was maintained at 2~3 MPa, and the reaction temperature was controlled at 30-40 °C. After the system pressure was stabilized and no longer decreased, the reaction was continued for 1 hour. Upon completion of the reaction, samples were taken and analyzed to ensure that the residual nitro compounds in the hydrogenation reaction solution were less than 0.5%. Subsequently, the catalyst was removed by filtration, and most of the solvent was firstly recovered by distillation at atmospheric pressure, and then purified by decompression distillation, finally 92.6 g of 4-(chlorodifluoromethoxy)aniline was obtained with a yield of 64.2%.
References
[1] Russian Journal of Organic Chemistry, 2002, vol. 38, # 2, p. 269 - 271
[2] Green Chemistry, 2018, vol. 20, # 1, p. 130 - 135
[3] Patent: CN104119238, 2016, B. Location in patent: Paragraph 0018; 0032; 0033; 0037; 0038
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13843 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
View Lastest Price from 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
39065-95-7
|
US $0.00-0.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
39065-95-7
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-08-29 | 4-(Chlorodifluoromethoxy)aniline
39065-95-7
|
US $0.00-0.00 / kg | 1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
39065-95-7
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-(CHLORO-DIFLUORO-METHOXY)-PHENYLAMINE
39065-95-7
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-(Chlorodifluoromethoxy)aniline
39065-95-7
- US $0.00-0.00 / kg
- 99%
- Jinan Ruitong Biotech Co., Ltd.
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