ChemicalBook CAS DataBase List 4-(CHLOROMETHYL)-2-(2-THIENYL)-1,3-THIAZOLE

4-(CHLOROMETHYL)-2-(2-THIENYL)-1,3-THIAZOLE synthesis

4synthesis methods

Product Name:4-(CHLOROMETHYL)-2-(2-THIENYL)-1,3-THIAZOLE
CAS Number:54679-16-2
Molecular formula:C8H6ClNS2
Molecular Weight:215.72

Benzoxazole, 5-(chloromethyl)-2-(2-thienyl)-

202594-98-7
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54986-94-6 Synthesis

[2-(2-THIENYL)-1,3-THIAZOL-4-YL]METHANOL

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4-(CHLOROMETHYL)-2-(2-THIENYL)-1,3-THIAZOLE

54679-16-2
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Yield:54679-16-2 65%

Reaction Conditions:

with thionyl chloride

Steps:

R.76 Reference Example 76

Reference Example 76 In substantially the same manner as in Reference Example 73, 2-(2-thienyl)-4-thiazolylmethanol was allowed to react with thionylchloride to give 4-chloromethyl-2-(2-thienyl)thiazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 54-55° C.

References:

US6211215,2001,B1