4-Chloroquinoline-6-carbaldehyde synthesis
- Product Name:4-Chloroquinoline-6-carbaldehyde
- CAS Number:676256-25-0
- Molecular formula:C10H6ClNO
- Molecular Weight:191.61
916811-99-9
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676256-25-0
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Yield:676256-25-0 84%
Reaction Conditions:
with 2,6-dimethylpyridine;sodium periodate;osmium(VIII) oxide in 1,4-dioxane;water;tert-butyl alcohol at 20; for 2 h;
Steps:
5.b
solution of the compound from Example 5a) (5.36 g, 28.35 mmol) in dioxane (15.0 ml.) and water (5.0 ml.) was treated with osmium tetroxide (7.1 ml_, 2.5% soln. in f-BuOH, 0.57 mmol), 2, 6-lutidine (6.6 ml_, 56.7 mmol), and sodium periodate (24.3 g, 113.4 mmol). After stirring 2 hours at ambient temperature, the reaction was quenched with water, extracted twice with CH2CI2, dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification via flash column chromatography (0-100% ethyl acetate in hexanes) provided
References:
WO2007/103756,2007,A2 Location in patent:Page/Page column 50-51
65340-70-7
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