6-BROMO-4-CHLOROQUINOLINE synthesis
- Product Name:6-BROMO-4-CHLOROQUINOLINE
- CAS Number:65340-70-7
- Molecular formula:C9H5BrClN
- Molecular Weight:242.5
145369-94-4
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65340-70-7
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Yield:65340-70-7 98.5%
Reaction Conditions:
with trichlorophosphate for 6 h;Heating / reflux;
Steps:
1.e
The solid 6-bromo-quinolin-4-ol (52 g, 232.1 mmol) was added to phosphorus oxychloride (213.5 mL) and then the mixture was heated to reflux for 6 h to afford a light brown solution. After cooling to room temperature, the excess phosphorus oxychloride was removed under the vacuum. The remaining residue was poured into an ice-containing beaker (2 L). Then, it was slowly neutralized with solid potassium carbonate and the resulting solids were collected by filtration and washed with water. After drying in air, 55.46 g (98.5% yield) of 6-bromo-4-chloro-quinoline was isolated as a light yellow solid: EI-HRMS m/e calcd for C9H5BrClN (M+) 240.9294, found 240.9297.
References:
Chen, Li;Chen, Shaoqing;Lou, Jianping;Sidduri, Achyutharao US2006/63805, 2006, A1 Location in patent:Page/Page column 9
98948-95-9
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65340-70-7
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$7.00/250mg
122794-99-4
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65340-70-7
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106-40-1
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$12.00/5g
65340-70-7
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101937-44-4
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$120.00/50mg
65340-70-7
274 suppliers
$7.00/250mg