Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro- synthesis
- Product Name:Thieno[3,2-d]pyrimidine-7-carboxylic acid, 4-chloro-
- CAS Number:1269667-57-3
- Molecular formula:C7H3ClN2O2S
- Molecular Weight:214.63
![methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate](/CAS/GIF/1246223-44-8.gif)
1246223-44-8
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$45.00/10mg
1269667-57-3
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$45.00/5mg
Yield: 81%
Reaction Conditions:
with lithium hydroxide monohydrate;water in tetrahydrofuran at 20; for 2 h;
Steps:
8.A
To a solution of methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate (2.00 g, 8.75 mmol) in tetrahydrofuran (60 mL) and water (20 mL) was added lithium hydroxide monohydrate (0.59 g, 14.0 mmol). The reaction mixture was stirred at room temperature for 2 hours, after which the volatiles were concentrated in vacuo. Water was added and a solid was obtain after filtration, which was rinsed with water and dried on a lyophilizer to afford 4-chlorothieno[3,2-fiT]pyrimidine-7-carboxylic acid (1.56 g, 81%).
References:
ARRAY BIOPHARMA INC.;GENENTECH, INC.;ALIAGAS, Ignacio;GRADL, Stefan;GUNZNER, Janet;MATHIEU, Simon;PULK, Rebecca;RUDOLPH, Joachim;WEN, Zhaoyang;GRINA, Jonas;HANSEN, Joshua D.;LAIRD, Ellen;MORENO, David;REN, Li;WENGLOWSKY, Steven Mark WO2011/25940, 2011, A1 Location in patent:Page/Page column 96
![4-chlorothieno[3,2-d]pyrimidine-7-carbaldehyde](/CAS/20180703/GIF/1318133-04-8.gif)
1318133-04-8
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1269667-57-3
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![THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE](/CAS/GIF/16234-10-9.gif)
16234-10-9
141 suppliers
$14.00/1g
1269667-57-3
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$45.00/5mg
![7-BROMOTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE](/CAS/GIF/31169-25-2.gif)
31169-25-2
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$55.00/50mg
1269667-57-3
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$45.00/5mg
85006-31-1
369 suppliers
$5.00/5g
1269667-57-3
24 suppliers
$45.00/5mg