4-(Cyclopropylethynyl)benzoic acid synthesis
- Product Name:4-(Cyclopropylethynyl)benzoic acid
- CAS Number:908247-29-0
- Molecular formula:C12H10O2
- Molecular Weight:186.21
Yield:908247-29-0 98%
Reaction Conditions:
Stage #1: 4-Bromobenzoic acidwith bis-triphenylphosphine-palladium(II) chloride;copper(l) iodide;triethylamine;triphenylphosphine;cesium fluoride in water at 20; for 0.25 h;Sealed tube;Inert atmosphere;
Stage #2: (2-cyclopropylethynyl)trimethylsilane in water at 80; for 16 h;Sealed tube;Inert atmosphere;
References:
Capani, Joseph S.;Cochran, John E.;Liang, Jianglin [Journal of Organic Chemistry,2019,vol. 84,# 14,p. 9378 - 9384]
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