ChemicalBook CAS DataBase List 4-DIETHYLAMINOBENZOIC ACID

4-DIETHYLAMINOBENZOIC ACID synthesis

7synthesis methods

Product Name:4-DIETHYLAMINOBENZOIC ACID
CAS Number:5429-28-7
Molecular formula:C11H15NO2
Molecular Weight:193.24

120-21-8 Synthesis

120-21-8
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5429-28-7
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$7.00/1g

Yield:5429-28-7 74%

Reaction Conditions:

with potassium hydroxide;sodium hydroxide in neat (no solvent)Heating;

Steps:

Synthesis of the p-Aminobenzoic Acids. General Procedure
General procedure: Potassium hydroxide (3.6 g, 64 mmol) and sodium hydroxide (2.4 g, 60 mmol) weremixed and quickly crushed in a porcelain dish. Then the corresponding aldehyde(15 mmol) was added and the mixture was heated on a hot-plate under stirring until thealdehyde melted and additionally 5 minutes. When liquid aldehydes were used, heatingwas continued until temperature reached 140C. After cooling, the crude solid productmixture was added to water (100 mL) and ice (30 g) and acidified with hydrochloric acidto pH 4. The precipitate was collected, dried and recrystallized from ethanol.

References:

Pietrzak, Marek;Jędrzejewska, Beata;Mądrzejewska, Dorota;Bajorek, Agnieszka [Organic Preparations and Procedures International,2017,vol. 49,# 1,p. 45 - 52]

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