ChemicalBook CAS DataBase List 4-Ethylacetophenone

4-Ethylacetophenone synthesis

13synthesis methods

Product Name:4-Ethylacetophenone
CAS Number:937-30-4
Molecular formula:C10H12O
Molecular Weight:148.2

100-41-4
335 suppliers
$5.00/5 g

75-36-5 Synthesis

75-36-5
558 suppliers
$17.92/100G

937-30-4
199 suppliers
$25.00/25g

Yield:937-30-4 86%

Reaction Conditions:

with aluminum (III) chloride in dichloromethane at -70 - -50; for 5 h;

Steps:

2.1
Example 2; Synthesis of 4-bromo-7-ethyl-6-methoxvcinnoline; [00187] Step 1. Aluminum (III) chloride (27 g, 202.49 mmol) was added to a chilled solution of 1-ethylbenzene (10.6 g, 99.85 mmol) in methylene chloride (100 mL) at -70 ⁰C. A solution of acetic anhydride (10.2 g, 99.91 mmol) in methylene chloride (20 mL) was added dropwise over 3 hr, while maintaining the temperature at -70 ⁰C. The resulting solution was maintained for 2 hr between -70 and -50⁰C, then added to a mixture of ice and hydrochloric acid (100 mL). The product was extracted with methylene chloride and the organic, dried, filtered, and concentrated to afford 15 g (86 % yield) of l-(4- ethylphenyl)ethanone as a colorless liquid.

References:

AMGEN INC.;MEMORY PHARMACEUTICALS CORPORATION WO2007/103260, 2007, A1 Location in patent:Page/Page column 59

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40307-11-7 Synthesis