(4-Fluoro-3-iodophenyl)methanol synthesis
- Product Name:(4-Fluoro-3-iodophenyl)methanol
- CAS Number:227609-87-2
- Molecular formula:C7H6FIO
- Molecular Weight:252.0248
227609-86-1
33 suppliers
$30.00/100mg
227609-87-2
25 suppliers
$93.00/250mg
Yield:-
Reaction Conditions:
with potassium iodide;sulfuric acid;sodium nitrite in water;
Steps:
2.B 4-Fluoro-3-iodobenzylalcohol
Example 2B 4-Fluoro-3-iodobenzylalcohol The product from Example 2A (7.0 g, 50 mmol) in water (100 mL) at 0° C. was treated slowly with concentrated sulfuric acid (30 mL) at a rate to maintain the temperature below 10° C. and then treated dropwise with an aqueous solution of sodium nitrite (3.45 g, 50 mmol). This solution was then added to a solution of potassium iodide (8.13 g, 50 mmol) in water (15 mL), heated to 60° C. for 2 hours, cooled and extracted with methylene chloride. The methylene chloride layer was washed with 10% sodium hydroxide, washed with 1M sodium thiosulfate, washed with 10% hydrochloric acid, washed with aqueous sodium bicarbonate, dried (sodium sulfate), filtered, and concentrated. The residue was purified by flash chromatography over silica gel (ethyl acetate/hexane 7:3) to provide 6.4 g of the title compound. 1H NMR (CDCl3) δ1.69 (t, 1H), 4.66 (d, 2H), 7.05 (t, 1H), 7.60 (d, 1H), 7.78 (dd, 1H).
References:
US2003/65182,2003,A1
7632-00-0
848 suppliers
$14.00/25g
227609-86-1
33 suppliers
$30.00/100mg
227609-87-2
25 suppliers
$93.00/250mg
2365-85-7
190 suppliers
$9.00/1g
227609-87-2
25 suppliers
$93.00/250mg