4-FLUORO-N-METHYLBENZAMIDE synthesis
- Product Name:4-FLUORO-N-METHYLBENZAMIDE
- CAS Number:701-49-5
- Molecular formula:C8H8FNO
- Molecular Weight:153.15
456-22-4
494 suppliers
$10.00/100 g
74-89-5
0 suppliers
$13.44/25ML
701-49-5
78 suppliers
$10.00/250mg
Yield:701-49-5 63%
Reaction Conditions:
Stage #1:4-Fluorobenzoic acid;methylamine with triethylamine in tetrahydrofuran;1,2-dichloro-ethane at 20; for 0.166667 h;
Stage #2: with benzotriazol-1-ol;dicyclohexyl-carbodiimide in tetrahydrofuran;1,2-dichloro-ethane at 70; for 3 h;
Steps:
4.D; D
To a stirred solution of 4-fluorobenzoic acid (200 mg, 1.43 mmol) in DCE (3 ml) at RT, was added a solution of methyl amine in THF (2 M, 1.43mmol) and NEt3 (198 μl, 1.43 mmol) and allowed to stir for ca. 10 mins. HOBt (221 mg, 1.43 mmol) and DCC (295 mg, 1.43 mmol)
References:
EVOTEC NEUROSCIENCES GMBH WO2009/135842, 2009, A1 Location in patent:Page/Page column 67-68
116332-54-8
118 suppliers
$6.00/1g
701-49-5
78 suppliers
$10.00/250mg
456-22-4
494 suppliers
$10.00/100 g
593-51-1
561 suppliers
$21.00/100g
701-49-5
78 suppliers
$10.00/250mg
