4-(HydroxyiMinoMethyl)benzaMidoxiMe, 97% synthesis
- Product Name:4-(HydroxyiMinoMethyl)benzaMidoxiMe, 97%
- CAS Number:932742-89-7
- Molecular formula:C8H9N3O2
- Molecular Weight:179.18
63476-93-7
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932742-89-7
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Yield:932742-89-7 77%
Reaction Conditions:
with hydroxylamine in methanol;water at 20; for 16 h;
Steps:
11
0069] Example 11. N'-Hydroxy-4-((hydroxyimino)methyl)benzamidine (15a). 13a(120 mg, 0.65 mmol), 50% NH2OH in H20 ( 119 1.95 mmol) in MeOH was stirred at rt for 16h, evaporated and purified by chromatography (silica gel, CH2Cl2:MeOH) to give 15a as a yellow solid (90 mg, 77%). ? NMR (300MHz, DMSO) δ= 11.29 (s, 1H), 9.71 (s, 1H), 8.13 (s, 1H), 7.68 (d, 7=8.4 Hz, 2H), 7.56 (d, 7=8.4 Hz, 2H), 5.82 (brs, 2H). ESI MS for [M+H]+= 179.95 Da.
References:
WO2012/83261,2012,A1 Location in patent:Page/Page column 18
105-07-7
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