4-IODO-N-METHOXY-N-METHYL-BENZAMIDE synthesis
- Product Name:4-IODO-N-METHOXY-N-METHYL-BENZAMIDE
- CAS Number:187617-01-2
- Molecular formula:C9H10INO2
- Molecular Weight:291.09
6638-79-5
587 suppliers
$6.00/25g
1711-02-0
163 suppliers
$10.00/1g
187617-01-2
24 suppliers
$266.00/1g
Yield:187617-01-2 93%
Reaction Conditions:
with pyridine in dichloromethane;ethyl acetate;
Steps:
30 O,N-Dimethyl-4-iodobenzenehydroxamic acid STR166
PREPARATION 30 O,N-Dimethyl-4-iodobenzenehydroxamic acid STR166 A solution of pyridine (104 g, 1.32 mol) in dichloromethane (150 ml) was added dropwise to a suspension of 4-iodobenzoyl chloride (251 g, 0.94 mol) and N,O-dimethylhydroxylamine hydrochloride (97 g, 0.94 mol) in dichloromethane (850 ml) at 0° C. The mixture was allowed to warm to room temperature and was stirred for 18 hours. The solution was evaporated under reduced pressure, the residue was dissolved in ethyl acetate (IL), and was then washed with dilute hydrochloric acid (2N, 3*400 ml) and saturated sodium bicarbonate solution (300 ml) and dried (Na2 SO4). The organic extract was evaporated under reduced pressure. The residue was purified by distillation to yield the title product (241 g, 93%), as a yellow oil b.p. 130° C. (0. Imm Hg), which was characterised by 1 H-N.M.R. spectroscopy (300 MHz, CDCl3): δ=3.32 (s,3H), 3.50 (s,3H), 7.40 (d,2H), 7.72 (d,2H) ppm.
References:
US6015825,2000,A
619-58-9
443 suppliers
$8.00/5g
6638-79-5
587 suppliers
$6.00/25g
187617-01-2
24 suppliers
$266.00/1g
1711-02-0
163 suppliers
$10.00/1g
1117-97-1
73 suppliers
inquiry
187617-01-2
24 suppliers
$266.00/1g
619-58-9
443 suppliers
$8.00/5g
187617-01-2
24 suppliers
$266.00/1g