ChemicalBook CAS DataBase List 4-IODO-N-METHOXY-N-METHYL-BENZAMIDE

4-IODO-N-METHOXY-N-METHYL-BENZAMIDE synthesis

5synthesis methods

Product Name:4-IODO-N-METHOXY-N-METHYL-BENZAMIDE
CAS Number:187617-01-2
Molecular formula:C9H10INO2
Molecular Weight:291.09

6638-79-5 Synthesis

6638-79-5
552 suppliers
$6.00/25g

1711-02-0 Synthesis

1711-02-0
162 suppliers
$10.00/1g

187617-01-2
20 suppliers
$266.00/1g

Yield:187617-01-2 93%

Reaction Conditions:

with pyridine in dichloromethane;ethyl acetate;

Steps:

30 O,N-Dimethyl-4-iodobenzenehydroxamic acid STR166

PREPARATION 30 O,N-Dimethyl-4-iodobenzenehydroxamic acid STR166 A solution of pyridine (104 g, 1.32 mol) in dichloromethane (150 ml) was added dropwise to a suspension of 4-iodobenzoyl chloride (251 g, 0.94 mol) and N,O-dimethylhydroxylamine hydrochloride (97 g, 0.94 mol) in dichloromethane (850 ml) at 0° C. The mixture was allowed to warm to room temperature and was stirred for 18 hours. The solution was evaporated under reduced pressure, the residue was dissolved in ethyl acetate (IL), and was then washed with dilute hydrochloric acid (2N, 3*400 ml) and saturated sodium bicarbonate solution (300 ml) and dried (Na₂ SO₄). The organic extract was evaporated under reduced pressure. The residue was purified by distillation to yield the title product (241 g, 93%), as a yellow oil b.p. 130° C. (0. Imm Hg), which was characterised by ¹ H-N.M.R. spectroscopy (300 MHz, CDCl₃): δ=3.32 (s,3H), 3.50 (s,3H), 7.40 (d,2H), 7.72 (d,2H) ppm.

References:

US6015825,2000,A