4-Isopropoxycyclohexanone synthesis
- Product Name:4-Isopropoxycyclohexanone
- CAS Number:69697-46-7
- Molecular formula:C9H16O2
- Molecular Weight:156.22
![8-Isopropoxy-1,4-dioxaspiro[4.5]decane](/CAS/20150408/GIF/950771-91-2.gif)
950771-91-2
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69697-46-7
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Yield:69697-46-7 100%
Reaction Conditions:
with hydrogenchloride in tetrahydrofuran;water at 20; for 18 h;
Steps:
26
A solution of the mixture of 8-[(1-methylethyl)oxy]-1 ,4-dioxaspiro[4.5]decane and 4-[(1- methylethyl)oxy]cyclohexanone (~4:1 ) (D25 , 4.89g, ~0.025mol) in tetrahydrofuran (10ml) at room temperature under argon was treated with 5M HCI acid (50ml) and stirred well for 18h. The reaction mixture was treated with water (150ml) and extracted with dichloromethane (2 x 80ml). The combined extract was washed with brine, dried (Na2SO4) and concentrated under vacuum to afford the title compound as a colourless oil (3.9g, 100%).1H NMR δ (CDCI3, 400 MHz): 1.19 (6H, d), 1.88-2.08 (4H, m), 2.22-2.32 (2H, m), 2.54- 2.65 (2H, m), 3.70-3.84 (2H, m).
References:
WO2007/107565,2007,A1 Location in patent:Page/Page column 61
![1,4-Dioxaspiro[4.5]decan-8-one](/CAS/GIF/4746-97-8.gif)
4746-97-8
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69697-46-7
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$54.00/100mg
![1,4-DIOXA-SPIRO[4.5]DECAN-8-OL](/CAS/GIF/22428-87-1.gif)
22428-87-1
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$6.00/1g
69697-46-7
42 suppliers
$54.00/100mg