4-(Isopropylamino)butanol synthesis
- Product Name:4-(Isopropylamino)butanol
- CAS Number:42042-71-7
- Molecular formula:C7H17NO
- Molecular Weight:131.22
13325-10-5
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42042-71-7
The general procedure for the synthesis of 4-(isopropylamino)butanol from 4-amino-1-butanol and acetone was as follows: 200 g of 4-amino-1-butanol (II) was dissolved in a solvent mixture of 400 ml of acetone and 1,000 ml of ethanol, to which was added 20 g of 10% Pd/C catalyst. The hydrogenation reaction was carried out at a hydrogen pressure of 10 atmospheres for 4 to 5 hours. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated to afford the target compound 4-(isopropylamino)butanol as a colorless oil in quantitative yield.
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Yield:42042-71-7 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol; under 7500.75 Torr;
Steps:
2 Example 2: Preparation of 4-(isopropylamino)-1-butanol (III)
200 gm of 4-amino-1-butanol (II) was dissolved in a mixed solvent of 400 ml of acetone and 1000 ml of ethanol and, after adding 20 gm of 10% Pd/C, hydrogenation was carried out under the pressure of 10 kg for 4-5 hours. The reaction solution was filtered to remove the catalyst and the filtrate obtained was concentrated to obtain desired compound in quantitative yield, as a colorless oily substance
References:
WO2017/60827,2017,A1 Location in patent:Page/Page column 11
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