(4-METHOXY-3-NITROPHENYL)ACETIC ACID synthesis
- Product Name:(4-METHOXY-3-NITROPHENYL)ACETIC ACID
- CAS Number:63304-80-3
- Molecular formula:C9H9NO5
- Molecular Weight:211.17
34837-88-2
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63304-80-3
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Yield: 80%
Reaction Conditions:
with lithium hydroxide monohydrate in tetrahydrofuran;water at 20; for 1 h;
Steps:
17.3 Step 3. 2-(4-methoxy-3-nitrophenyl)acetic acid
Methyl 2-(4-methoxy-3-nitrophenyl)acetate (8.0 g, 35.6 mmol) was dissolved in tetrahydrofuran (80 mL) and water (20 mL). Lithium hydroxide monohydrate (4.5 g, 106.7 mmol) was slowly added to the reaction solution, and the reaction was stirred at room temperature for 1 hour. Tetrahydrofuran was removed under reduced pressure and the pH was adjusted to 3 with hydrochloric acid (3N). The reaction mixture was stirred for 15 minutes and then filtered. The filter cake was washed with 50 mL of water and dried to give 2-(4-methoxy-3-nitrophenypacetic acid. (6.0 g, 28.4 mmol, yield: 80%). 1H NMR (400 MHz, DMSO-d6) δ 12.46 (m, 1H), 7.79 (d, J=2.4 Hz, 1H), 7.56 (dd, J=2.4 and 8.8 Hz, 1H), 7.32 (d), J=8.8 Hz, 1H), 3.91(s, 3H), 3.64(s, 2H).
References:
Shanghai Zhimeng Biophama Co., Ltd.;CHEN, Huanming US2019/152963, 2019, A1 Location in patent:Paragraph 0290; 0297-0299
104-01-8
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10463-20-4
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74-88-4
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![5(4H)-Oxazolone,4-[(4-methoxy-3-nitrophenyl)methylene]-2-phenyl-](/CAS/20180527/GIF/904-42-7.gif)
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63304-80-3
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