4-Methoxy-7H- Pyrrolo[2,3-d] pyriMidin-2-aMine synthesis
- Product Name:4-Methoxy-7H- Pyrrolo[2,3-d] pyriMidin-2-aMine
- CAS Number:84955-32-8
- Molecular formula:C7H8N4O
- Molecular Weight:164.16
124-41-4
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![2-Amino-4-chloropyrrolo[2,3-d]pyrimidine](/CAS/GIF/84955-31-7.gif)
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Yield:84955-32-8 164 mg
Reaction Conditions:
in methanol at 20;
Steps:
12.1 Step 1: Synthesis of 4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amine (E47)
A 30% sodium methoxide solution in methanol (400 mg, 2.22 mmol) was added to an eggplant flask, and 10 mLof methanol was added. 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (168 mg, 1.00 mmol) was added andstirred at room temperature overnight. The solvent was evaporated to dryness over rotary evaporation, water wasadded, and ethyl acetate was evaporated. The target compound was obtained in 164 mg.
References:
CN109810110,2019,A Location in patent:Paragraph 0174-0177
![2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine](/CAS/GIF/7355-55-7.gif)
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![Ethanol, 2-[(2-amino-7H-pyrrolo[2,3-d]pyrimidin-4-yl)thio]-](/CAS/20210305/GIF/84981-48-6.gif)
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84955-32-8
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