4-METHYL-PIPERAZINE-1-CARBONITRILE synthesis
- Product Name:4-METHYL-PIPERAZINE-1-CARBONITRILE
- CAS Number:50451-22-4
- Molecular formula:C6H11N3
- Molecular Weight:125.1716
Yield:50451-22-4 88.5%
Reaction Conditions:
with sodium hydrogencarbonate in dichloromethane;water at 0 - 20;
Steps:
17.1 step 1 preparation of 4-methylpiperazine-1-carbonitrile 8b
Sodium bicarbonate (5.04 g, 60 mmol) and 4-methylpiperazine (2.00 g, 20 mmol) were dissolved in a mixed solvent of 45 mL of water and 10 mL of dichloromethane, and cooled to 0 ° C in an ice bath to give cyanogen bromide ( 2.62 g, 25 mmol) was slowly added dropwise to 15 mL of dichloromethane, and the mixture was stirred at 0 ° C for 0.5 hour, then transferred to room temperature and stirred overnight. The reaction mixture was extracted with methylene chloride. 4-methylpiperazine-1-carbonitrile 8b, 2.44 g of a yellow oil, yield 88.5%.
References:
CN104211708,2018,B Location in patent:Paragraph 0282-0284
