Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 4,N-DIMETHYL-N-METHOXYBENZAMIDE
122334-36-5

4,N-DIMETHYL-N-METHOXYBENZAMIDE synthesis

13synthesis methods
p-Toluic acid

99-94-5

N-methoxymethylamine

1117-97-1

4,N-DIMETHYL-N-METHOXYBENZAMIDE

122334-36-5

GENERAL PROCEDURE: Methoxymethylamine (0.360 g, 6.0 mmol) and p-methylbenzoic acid (0.244 g, 2.0 mmol) were dissolved in anhydrous toluene (10 mL) and stirred for 10 min at 0 °C. Subsequently, a solution of phosphorus trichloride (0.137 g, 1.0 mmol) in anhydrous toluene (2 mL) was slowly added dropwise to the above mixture. The reaction mixture was gradually warmed up to room temperature, followed by stirring at 60 °C for 0.5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the mixture was cooled to room temperature. The reaction was quenched with saturated sodium bicarbonate solution (20 mL) and extracted with ethyl acetate (3 x 10 mL). The organic layers were combined and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by column chromatography (silica gel, petroleum ether-ethyl acetate, 3:2) to afford the colorless oily target product N-methoxy-N,4-dimethylbenzamide (320 mg, 97% yield).

-

Yield: 98%

Reaction Conditions:

Stage #1:p-Toluic acid;N,0-dimethylhydroxylamine in toluene at 0; for 0.166667 h;
Stage #2: with phosphorus trichloride in toluene at 20 - 60; for 0.5 h;

Steps:

N-Methoxy-N-methylbenzamide (3a);38,39 Typical Procedure
General procedure: A solution of NHMe(OMe) (0.360 g, 6.0 mmol) and benzoic acid (0.244 g, 2.0 mmol) was stirred in dry toluene (10 mL) at 0 °C for 10 min. A solution of PCl3 (0.137 g, 1.0 mmol) in dry toluene (2 mL) was then added dropwise to the mixture. The mixture was warmed to r.t. slowly and then stirred at 60 °C for 0.5 h. When the reaction was complete (TLC monitoring), the mixture was cooled to r.t. The mixture was then quenched with sat. NaHCO3 soln (20 mL) and extracted with EtOAc (3 × 10 mL). The combined organic layers were dried (anhyd MgSO4). The solvent was removed in vacuo.The product was purified by column chromatography (silica gel, petroleum ether-EtOAc, 3:2) to give pure 3a as a colorless oil; yield: 320 mg (97%).

References:

Niu, Teng;Wang, Ke-Hu;Huang, Danfeng;Xu, Changming;Su, Yingpeng;Hu, Yulai;Fu, Ying [Synthesis,2014,vol. 46,# 3,art. no. SS-2013-H0629-OP,p. 320 - 330]

4,N-DIMETHYL-N-METHOXYBENZAMIDE Related Search: