4-nitro-6-fluoroindazole synthesis
- Product Name:4-nitro-6-fluoroindazole
- CAS Number:885520-14-9
- Molecular formula:C7H4FN3O2
- Molecular Weight:181.12
168770-44-3
885520-14-9
5-Fluoro-3-nitro-2-methylaniline (50 mg, 0.294 mmol) was used as starting material and dissolved in acetic acid (AcOH, 10 mL). Aqueous sodium nitrite (3 mL, containing 44.6 mg, 0.588 mmol of sodium nitrite) was slowly added at 0 °C. The reaction mixture was then warmed to room temperature and stirred continuously for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the reaction was terminated after confirming the complete consumption of raw materials. The final product 4-nitro-6-fluoroindazole was obtained as 18.3 mg of orange colored powder with 43.5% yield.
168770-44-3
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885520-14-9
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$62.00/100mg
Yield: 43.5%
Reaction Conditions:
with acetic acid;sodium nitrite in water at 0 - 20; for 6 h;
Steps:
3.3 3Synthesis of compound LWQ-145:
Starting material 5b (50 mg, 0.294 mmol) was dissolved in AcOH (10 mL).Add an aqueous solution (3 mL) of sodium nitrite (44.6 mg, 0.588 mmol) at 0 ° C, add rt, stir for 6 h;TLC showed that the starting material was completely reacted, and finally received 18.3 mg of an orange powder, yield: 43.5%.
References:
Xihua University;Yang Lingling;Qian Shan;Li Guobo;Chen Feng;Li Chao;He Yanying;Wang Zhouyu;Lai Peng CN108689937, 2018, A Location in patent:Paragraph 0081; 0082; 0087; 0088
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885520-14-9
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885520-14-9
64 suppliers
$62.00/100mg