4-(propan-2-yloxy)butan-2-ol synthesis
- Product Name:4-(propan-2-yloxy)butan-2-ol
- CAS Number:40091-57-4
- Molecular formula:C7H16O2
- Molecular Weight:132.2
Yield:40091-57-4 13%
Reaction Conditions:
with C57H63N4OP2Ru(1+)*Cl(1-);potassium tert-butylate at 50; for 22 h;Inert atmosphere;
Steps:
Method A: Hydroalkoxylation of 3-buten-2-ol (1a) (Table 2)
General procedure: To an argon-purged reaction tube equipped with J-Young stop valve was added Ru6 (0.03 mmol), KOBut (0.06 mmol),3-buten-2-ol (1a) (2.0 mmol), and alcohols (8.6 mmol)as a substrate and solvent. The mixture was degassed by usingFPT cycles and then purged with argon again. The reaction mixture was stirred at the corresponding temperature for 22h. Then, to the mixture was added triphenylmethane (0.2 mmol) as an internal standard for NMR yield. After a part ofthe solution was evaporated and carefully dried under the vacuum, the yield was measured by 1H NMR.
References:
Nakamura, Yushi;Ohta, Tetsuo;Oe, Yohei [Chemistry Letters,2018,vol. 47,# 3,p. 288 - 291] Location in patent:supporting information
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