(4-propylphenyl)boronic Acid synthesis
- Product Name:(4-propylphenyl)boronic Acid
- CAS Number:1359844-00-0
- Molecular formula:C15H23BO2
- Molecular Weight:246.15
Yield:1359844-00-0 90%
Reaction Conditions:
with potassium acetate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in N,N-dimethyl-formamide at 110; for 12 h;
Steps:
1.1
[Experimental embodiment 1]: preparation of the compound in formula (I-2)Step 1: synthesize the compound in formula (1-A) (hereinafter “compound (1-A)”).First, 3.0 grams (15 millimoles) of 4-bromo-l-propyl benzene in formula (1) and 4.2 grams (16.5 millimoles) of bis(pinacolate)diboron, and 4.4 grams (45 millimoles) of potassium acetate are dissolved in 30 milliliters (mL) of dimethylformamide (DMF). After the above mixture is stirred to a uniform state, 0.05 gram of 1,1'-bis((diphenylphosphino)ferrocene)dichloropalladium is added, and the resulting mixture is heated to 110° C. and stirred for 12 hours. After reacting, 50 mL of water is added to the mixture, and the mixture is extracted by ethyl acetate. An organic layer of the mixture solution is desiccated by waterless magnesium sulfate and is filtered and concentrated. Afterwards, column chromatography (silicone, hexane) is performed to purify the product, thereby obtaining 3.3 grams of a light yellow solid compound (1-A). The yield is 90%.
References:
US2012/264984,2012,A1 Location in patent:Page/Page column 2
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