4-Pyrimidinecarbonyl chloride (9CI) synthesis
- Product Name:4-Pyrimidinecarbonyl chloride (9CI)
- CAS Number:184951-32-4
- Molecular formula:C5H3ClN2O
- Molecular Weight:142.54
31462-59-6
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184951-32-4
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Yield:184951-32-4 99%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 0; for 2 h;Inert atmosphere;
Steps:
1 Step 1 - Pyrimidine-4-carbonyl chloride
To a solution of pyrimidine-4-carboxylic acid (800 mg, 6.45 mmol, CAS 31462- 59-6) in DCM (8.00 mL) was added (COCl)2 (1.64 g, 12.8 mmol) and DMF (47.1 mg, 644 umol) at 0 °C and the mixture was stirred at 0 °C for 2 hrs. On completion, the mixture was concentrated in vacuo to give the title compound (918 mg, 99% yield) as black solid. LC-MS (ESI+) m/z 139.1 (M+1)+ (quenched by MeOH).
References:
WO2020/264499,2020,A1 Location in patent:Paragraph 00920; 002770-002772
3438-46-8
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184951-32-4
15 suppliers
$49.47/1mg: