ChemicalBook CAS DataBase List 4-TERT-BUTYL-4'-CHLOROBENZOPHENONE

4-TERT-BUTYL-4'-CHLOROBENZOPHENONE synthesis

10synthesis methods

Product Name:4-TERT-BUTYL-4'-CHLOROBENZOPHENONE
CAS Number:67743-49-1
Molecular formula:C17H17ClO
Molecular Weight:272.77

3972-65-4 Synthesis

3972-65-4
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Benzoic acid, 4-chloro-, 2-hydroxyethyl ester

19824-38-5
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67743-49-1
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$294.00/1g

Yield:67743-49-1 91 mg

Reaction Conditions:

Stage #1: ethylene glycol mono(4'-chlorobenzoate)with TurboGrignard in tetrahydrofuran at 0; for 0.0833333 h;Schlenk technique;Inert atmosphere;
Stage #2: 1-bromo-4-tert-butylbenzenewith magnesium;lithium chloride in tetrahydrofuran at 0;Inert atmosphere;
Stage #3: in tetrahydrofuran at 25; for 0.166667 h;Flow reactor;Inert atmosphere;

References:

Heinz, Benjamin;Djukanovic, Dimitrije;Ganiek, Maximilian A.;Martin, Benjamin;Schenkel, Berthold;Knochel, Paul [Organic Letters,2020,vol. 22,# 2,p. 493 - 496] Location in patent:supporting information

7099-90-3 Synthesis