ChemicalBook CAS DataBase List 4-(TetraMethyl-1,3,2-dioxaborolan-2-yl)butan-2-one

4-(TetraMethyl-1,3,2-dioxaborolan-2-yl)butan-2-one synthesis

5synthesis methods

Product Name:4-(TetraMethyl-1,3,2-dioxaborolan-2-yl)butan-2-one
CAS Number:100818-32-4
Molecular formula:C10H19BO3
Molecular Weight:198.07

78-94-4
0 suppliers
$32.86/25ml

73183-34-3
586 suppliers
$6.00/5g

4-(TetraMethyl-1,3,2-dioxaborolan-2-yl)butan-2-one

100818-32-4
14 suppliers
$45.00/50mg

Yield:100818-32-4 96%

Reaction Conditions:

with 2-((1,3-bis(N-butylimidazol-2-ylidene)phenylene)(dimethylamido)bis(iodo))rhodium(III);2-((1,3-bis(N-butylimidazol-2-ylidene)phenylene)(dimethylamido)bis(chloro))rhodium(III) in ethanol at 22; for 1 h;Catalytic behavior;Sealed tube;Solvent;

Steps:

4.5 General procedure for catalyses

General procedure: A 1 dram vial containing a magnetic stir bar was charged with α,β-unsaturated compound (0.0735mmol), bis(pinacolato)diboron (0.184mmol), pre-catalyst A (2.00mg, 2.94μmol), and solvent (0.700mL). The vial was closed and stirred vigorously for 1h at 22°C during which time a dark precipitate was observed to form. After 1h, a 10μL aliquot was passed through a short plug of celite and a 0.45 um PTFE filter. It was injected into the GC-MS to determine conversion. The crude reaction mixture was then filtered through a plug of celite. Volatiles were then removed under reduced pressure resulting in an oil. ¹H NMR and HRMS was taken of the crude product to confirm the borylated product. The crude product was then purified by silica gel chromatography to determine an isolated yield.

References:

Reilly, Sean W.;Akurathi, Gopalakrishna;Box, Hannah K.;Valle, Henry U.;Hollis, T. Keith;Webster, Charles Edwin [Journal of Organometallic Chemistry,2016,vol. 802,p. 32 - 38]