4-(Trifluoromethoxy)benzylisothiocyanate synthesis
- Product Name:4-(Trifluoromethoxy)benzylisothiocyanate
- CAS Number:128273-52-9
- Molecular formula:C9H6F3NOS
- Molecular Weight:233.21
463-71-8
152 suppliers
$32.00/10g
93919-56-3
159 suppliers
$10.00/1g
128273-52-9
12 suppliers
$75.00/250mg
Yield:128273-52-9 62%
Reaction Conditions:
Stage #1: 4-(trifluoromethoxy)benzyl aminewith triethylamine in tetrahydrofuran at 0; for 0.166667 h;
Stage #2: thiophosgene in tetrahydrofuran at 0 - 20; for 3.33333 h;
References:
García-Reyes, Balbina;Witt, Lydia;Jansen, Bj?rn;Karasu, Ebru;Gehring, Tanja;Leban, Johann;Henne-Bruns, Doris;Pichlo, Christian;Brunstein, Elena;Baumann, Ulrich;Wesseler, Fabian;Rathmer, Bernd;Schade, Dennis;Peifer, Christian;Knippschild, Uwe [Journal of Medicinal Chemistry,2018,vol. 61,# 9,p. 4087 - 4102] Location in patent:supporting information