4-(TRIFLUOROMETHOXY)THIOPHENOL synthesis
- Product Name:4-(TRIFLUOROMETHOXY)THIOPHENOL
- CAS Number:169685-29-4
- Molecular formula:C7H5F3OS
- Molecular Weight:194.17
94108-56-2
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7440-66-6
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169685-29-4
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$31.00/1g
Yield: 47%
Reaction Conditions:
with sodium bicarbonate in sulfuric acid;water;ethyl acetate
Steps:
13 Preparation of 2-amino-9-[2-[bis(2,2,2-trifluoroethyl)-phosphonylmethoxy]ethyl]-6-p-trifluoromethoxyphenylthiopurine (Compound No. 35)
Example 13 Preparation of 2-amino-9-[2-[bis(2,2,2-trifluoroethyl)-phosphonylmethoxy]ethyl]-6-p-trifluoromethoxyphenylthiopurine (Compound No. 35) Zinc powder (3.1 g) was added to a suspension of p-trifluoromethoxybenzenesulfonyl chloride (1.36 ml) in concentrated sulfuric acid (3.4 ml) and water (20 ml), and the suspension was stirred at 0° C. for 18 hours and heated under reflux for 6 hours. The mixture was added with ethyl acetate, washed with water, saturated aqueous solution of sodium hydrogen carbonate, and saturated brine, and then concentrated under reduced pressure to give p-trifluoromethoxybenzenethiol (0.73 g, 47%).
References:
Mitsubishi Chemical Corporation US5840716, 1998, A
828-27-3
332 suppliers
$5.00/1g
169685-29-4
94 suppliers
$31.00/1g