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ChemicalBook CAS DataBase List 4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID ETHYL ESTER

4-(4,4-DIMETHYL-PIPERIDIN-1-YL)-BENZOIC ACID ETHYL ESTER synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 3.64 g / AcCl / 1,2-dichloro-ethane / 1 h / Heating
2: 76 percent / BF3*Et2O; NaBH4 / various solvent(s) / 4.25 h / 0 - 20 °C

References:

Wendt, Michael D.;Shen, Wang;Kunzer, Aaron;McClellan, William J.;Bruncko, Milan;Oost, Thorsten K.;Ding, Hong;Joseph, Mary K.;Zhang, Haichao;Nimmer, Paul M.;Ng, Shi-Chung;Shoemaker, Alexander R.;Petros, Andrew M.;Oleksijew, Anatol;Marsh, Kennan;Bauch, Joy;Oltersdorf, Tilman;Belli, Barbara A.;Martineau, Darlene;Fesik, Stephen W.;Rosenberg, Saul H.;Elmore, Steven W. [Journal of Medicinal Chemistry,2006,vol. 49,# 3,p. 1165 - 1181]

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