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42092-05-7

P,P'-[(1,2-Phenylene)bis(Methylene)]bisphosphonic Acid P,P,P',P'-tetraethyl ester synthesis

2synthesis methods
-

Yield:42092-05-7 93%

Reaction Conditions:

at 160; for 4 h;Inert atmosphere;Arbuzov reaction;

References:

Flaherty, Daniel P.;Kiyota, Tomomi;Dong, Yuxiang;Ikezu, Tsuneya;Vennerstrom, Jonathan L. [Journal of Medicinal Chemistry,2010,vol. 53,# 22,p. 7992 - 7999] Location in patent:supporting information; experimental part