4-(2-methyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE) synthesis
- Product Name:4-(2-methyl-2H-tetrazol-5-yl)aniline(SALTDATA: FREE)
- CAS Number:436092-89-6
- Molecular formula:C8H9N5
- Molecular Weight:175.19
43131-48-2
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436092-89-6
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Yield:436092-89-6 96%
Reaction Conditions:
with hydrogen;palladium on activated charcoal in ethanol; under 3000.3 Torr; for 17 h;
Steps:
2
Step 2: 4-(2-Methyl-2H-tetrazol-5-yl)-phenylamine[00336] A mixture of 2-methyl-5-(4-nitro-phenyl)-2H-tetrazole (0.26Og, 1.27mmol) and palladium on charcoal (53.6mg) in ethanol (5OmL) is stirred in high pressure reactor under H2 at 4 bars for 17 hours. The catalyst is removed by filtration through Celite 521, washing with EtOH. The filtrates are combined and concentrated in vacuo to afford the title compound as a white solid (0.213g, 96%). HPLC (254nm) 1.50min (89%)
References:
WO2007/131991,2007,A1 Location in patent:Page/Page column 83
46047-18-1
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436092-89-6
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16687-60-8
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436092-89-6
8 suppliers
$45.00/10mg