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ChemicalBook CAS DataBase List IN1579, (E)-2,3-bis(5-bromothiophen-2-yl)acrylonitrile
439588-79-1

IN1579, (E)-2,3-bis(5-bromothiophen-2-yl)acrylonitrile synthesis

2synthesis methods
4701-17-1 Synthesis
5-Bromothiophene-2-carbaldehyde

4701-17-1
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71637-37-1 Synthesis
(5-BROMO-THIOPHEN-2-YL)-ACETONITRILE

71637-37-1
60 suppliers
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IN1579, (E)-2,3-bis(5-bromothiophen-2-yl)acrylonitrile

439588-79-1
15 suppliers
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Yield:439588-79-1 69%

Reaction Conditions:

with sodium methylate in methanol at 20; for 24 h;

Steps:

1.1

(1) Add 4.7g 5-bromothiophene-2-carboxaldehyde (compound A1), 5.0g 2-(5-bromothiophene 2-)acetonitrile (compound B1), 1.3g sodium methoxide and 50mL methanol to 100mL round bottom In the flask, the reaction was stirred at room temperature for 24 hours to precipitate a large amount of solids. The crude product was filtered and further separated and purified by silica gel chromatography with dichloromethane as the eluent to obtain 6.5g of yellow solid: E-2,3-bis(5-bromothiophene) Acrylonitrile (Compound C1), its yield: 69%.

References:

CN111303139,2020,A Location in patent:Paragraph 0066; 0068-0070