IN1579, (E)-2,3-bis(5-bromothiophen-2-yl)acrylonitrile synthesis
- Product Name:IN1579, (E)-2,3-bis(5-bromothiophen-2-yl)acrylonitrile
- CAS Number:439588-79-1
- Molecular formula:C11H5Br2NS2
- Molecular Weight:375.1
Yield:439588-79-1 69%
Reaction Conditions:
with sodium methylate in methanol at 20; for 24 h;
Steps:
1.1
(1) Add 4.7g 5-bromothiophene-2-carboxaldehyde (compound A1), 5.0g 2-(5-bromothiophene 2-)acetonitrile (compound B1), 1.3g sodium methoxide and 50mL methanol to 100mL round bottom In the flask, the reaction was stirred at room temperature for 24 hours to precipitate a large amount of solids. The crude product was filtered and further separated and purified by silica gel chromatography with dichloromethane as the eluent to obtain 6.5g of yellow solid: E-2,3-bis(5-bromothiophene) Acrylonitrile (Compound C1), its yield: 69%.
References:
CN111303139,2020,A Location in patent:Paragraph 0066; 0068-0070
20893-30-5
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