TERT-BUTYL4-(CYANO(PHENYL)METHYL)PIPERAZINE-1-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL4-(CYANO(PHENYL)METHYL)PIPERAZINE-1-CARBOXYLATE
- CAS Number:444891-21-8
- Molecular formula:C17H23N3O2
- Molecular Weight:301.38
77278-38-7
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Yield:444891-21-8 88%
Reaction Conditions:
Stage #1: 4-benzoylpiperazine-1-carboxylic acid tert-butyl esterwith bis(triphenylphosphine)iridium(I) carbonyl chloride in toluene at 20; for 0.0833333 h;
Stage #2: with 1,1,3,3-Tetramethyldisiloxane in toluene at 20; for 0.0833333 h;
Stage #3: with trimethylsilyl cyanide in toluene at 20; for 0.5 h;
References:
Fuentes de Arriba, ángel L.;Lenci, Elena;Sonawane, Mahendra;Formery, Odilon;Dixon, Darren J. [Angewandte Chemie - International Edition,2017,vol. 56,# 13,p. 3655 - 3659][Angew. Chem.,2017,vol. 129,# 13,p. 3709 - 3713,5] Location in patent:supporting information
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