1H-Pyrrolo[2,3-c]pyridine-7-carboxylic acid, 4-fluoro- synthesis
- Product Name:1H-Pyrrolo[2,3-c]pyridine-7-carboxylic acid, 4-fluoro-
- CAS Number:446284-56-6
- Molecular formula:C8H5FN2O2
- Molecular Weight:180.14
![1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,4-fluoro-(9CI)](/CAS/GIF/446284-50-0.gif)
446284-50-0
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446284-56-6
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Yield:446284-56-6 56%
Reaction Conditions:
with hydrogenchloride;methanol in water at 90; for 16 h;
Steps:
General Procedure for the Preparation of 4
A mixture of 3 (800 mg, 4.96 mmol) in MeOH (10 mL) and conc. HCl (10 mL) was stirred at 90°C for 16 h. TLC (petroleum ether: ethyl acetate = 2:1, Rf = 0.01) showed that the reaction wascomplete. The organic solvent was evaporated, and the precipitate was filtered off and dried to giveA mixture of 3 (800 mg, 4.96 mMol) in MeOH (10 mL) and conc. HCl (10 mL) was stirred at 90 Cfor 16 h. TLC (petroleum ether: ethyl acetate = 2:1, Rf = 0.01) showed that the reaction was complete.The organic solvent was evaporated, and the precipitate was filtered o and dried to give 4 (500 mg,56% yield) as a brown solid. 1H-NMR (400 MHz MeOD): 8.39 (d, J = 4.0 Hz, 1 H), 8.23 (d, J = 2.8 Hz,1 H), 7.15 (d, J = 3.2 Hz, 1 H).
References:
Meuser, Megan E.;Rashad, Adel A.;Ozorowski, Gabriel;Dick, Alexej;Ward, Andrew B.;Cocklin, Simon [Molecules,2019,vol. 24,# 8,art. no. 1581]
![1H-Pyrrolo[2,3-c]pyridine, 4-fluoro-7-(1,2,4-oxadiazol-3-yl)-](/CAS/20210305/GIF/446284-54-4.gif)
446284-54-4
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446284-56-6
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![1H-Pyrrolo[2,3-c]pyridine, 7-broMo-4-fluoro-](/CAS/GIF/446284-38-4.gif)
446284-38-4
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446284-56-6
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652160-72-0
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446284-56-6
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6628-77-9
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446284-56-6
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$220.00/50mg