methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride synthesis

1synthesis methods

Product Name:methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride
CAS Number:459133-43-8
Molecular formula:C10H13BrClNO2
Molecular Weight:294.5727

67-56-1 Synthesis

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methyl (R)-2-amino-3-(4-bromophenyl)propanoate hydrochloride

459133-43-8
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Yield:459133-43-8 241 g

Reaction Conditions:

with thionyl chloride at 65; for 1 h;

Steps:

1.1; 2.1

1) Add 250g 4-bromo-D-phenylalanine and 1.25L methanol to the reaction bottle, and drop 108.85ml thionylchloride, After the addition, the temperature is raised to 65 degrees, and the reaction is kept for 1 hour.Reduce compression crystallization at 40 ° C to obtain 241g of 4-bromo-D-phenylalanine methyl ester hydrochloride;

References:

CN108299226,2018,A Location in patent:Paragraph 0016; 0027-0028; 0037-0038