ethyl 2-amino-4-(3-chlorophenyl)thiophene-3-carboxylate synthesis
- Product Name:ethyl 2-amino-4-(3-chlorophenyl)thiophene-3-carboxylate
- CAS Number:473438-03-8
- Molecular formula:C13H12ClNO2S
- Molecular Weight:281.76
Yield:473438-03-8 93%
Reaction Conditions:
Stage #1: ethyl 2-cyanoacetate;3'-Chloroacetophenonewith titanium tetrachloride in dichloromethane at 0; for 0.5 h;
Stage #2: with pyridine in dichloromethane at 0 - 20; for 2 h;
Stage #3: with sulfur;diethylamine in tetrahydrofuran at 20;
References:
Aurelio, Luigi;Valant, Celine;Flynn, Bernard L.;Sexton, Patrick M.;White, Jonathan M.;Christopoulos, Arthur;Scammells, Peter J. [Journal of Medicinal Chemistry,2010,vol. 53,# 18,p. 6550 - 6559] Location in patent:experimental part
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