TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE synthesis
- Product Name:TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE
- CAS Number:479226-10-3
- Molecular formula:C15H21N3O3
- Molecular Weight:291.35
149806-06-4
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57260-71-6
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479226-10-3
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$72.00/100mg
Yield:479226-10-3 89.7%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in ethylene glycol dimethyl ether at 120; for 6.5 h;
Steps:
1.1 Step 1: tert-butyl 4-(5-formylpyridin-2-yl)piperazine-1-carboxylate
Compound 6-bromonicotinaldehyde (1.0 g, 5.376 mmol), N-Boc-piperazine (1.0 g, 5.376 mmol) and DIEA (2.5 mL) were added to 10 mL of DME, and the mixture was warmed to 120 ° C and stirred for 6.5 hours. Water was added, and the mixture was extracted with EA, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated to obtain 1.4 g of a yellow solid (yield: 89.7%).
References:
CN109824670,2019,A Location in patent:Paragraph 0076-0079