2-Bromopyridine-5-carbaldehyde synthesis
- Product Name:2-Bromopyridine-5-carbaldehyde
- CAS Number:149806-06-4
- Molecular formula:C6H4BrNO
- Molecular Weight:186.01
154321-32-1
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149806-06-4
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Yield:149806-06-4 92%
Reaction Conditions:
with calcium carbonate in water at 105; for 16 h;
Steps:
A.1 Preparation of 6-bromonicotinaldehyde (Ib)
A solution of intermediate Ia (3.650 g, 11.07 mmol), calcium carbonate (2.437 g,24.35 mmol) in water (80m1) was stirred at 105°C for 16 hours. The cooled mixture was diluted with water and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaC1, dried over MgSO4, filtered and evaporated to give intermediate lb (1.890 g, 92%). ‘H NMR (500 MHz, CDC13) ö 10.05 (s, 1H), 8.78(d, J= 2.2 Hz, 1H), 7.98 (dd, J= 8.2, 2.4 Hz, 1H), 7.65 (d, J= 8.2 Hz, 1H).
References:
AB SCIENCE;MOUSSY, Alain;BENJAHAD, Abdellah;PEZ, Didier;SANDRINELLI, Franck;MARTIN, Jason;PICOUL, Willy;CHEVENIER, Emmanuel WO2016/124747, 2016, A1 Location in patent:Page/Page column 58; 59
624-28-2
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149806-06-4
399 suppliers
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101990-45-8
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149806-06-4
399 suppliers
$5.00/1g