ChemicalBook CAS DataBase List 4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)

4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI) synthesis

4synthesis methods

Product Name:4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)
CAS Number:405174-48-3
Molecular formula:C8H7NO2
Molecular Weight:149.15

2H-Pyrano[3,2-b]pyridine,3,4-dihydro-4-methylene-(9CI)

405174-46-1
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4H-Pyrano[3,2-b]pyridin-4-one,2,3-dihydro-(9CI)

405174-48-3
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Yield:405174-48-3 45%

Reaction Conditions:

with dimethylsulfide;ozone in ethanol;dichloromethane at -78 - 20; for 1 h;

Steps:

2.3 Synthesis of S4
Intermediate S3 (3 g, 20.4 mmol) was added to a round bottom flask, dissolved in 150 ml of dichloromethane, and the reaction liquid was cooled to -78 ° C using a dry ice-ethanol system, and then subjected to ozone oxidation.After the reaction liquid became dark blue, ozone was stopped, and then 30 ml of dimethyl sulfide was added to the reaction liquid, and the temperature was naturally raised to room temperature. After stirring for one hour, the plate was plated, and the reaction of the starting material was confirmed by TLC. Silica gel was added to the reaction solution to spin dry sand, and purified by column chromatography (from dichloromethane: methanol = 300:1 → dichloromethane: methanol = 50:1)A milky white powder S4 was obtained with a yield of 45%.

References:

Chinese Academy Of Sciences Shanghai Organic Chemistry Institute;Zhu Jidong;Yi Jianhua;Chen Ge CN109651357, 2019, A Location in patent:Paragraph 0091; 0100-0103

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6602-32-0 Synthesis

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405174-48-3
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405174-45-0 Synthesis

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405174-48-3
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References

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