5-(2-ETHOXY-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE synthesis
- Product Name:5-(2-ETHOXY-PHENYL)-[1,3,4]THIADIAZOL-2-YLAMINE
- CAS Number:50616-29-0
- Molecular formula:C10H11N3OS
- Molecular Weight:221.28
Yield:50616-29-0 57.5%
Reaction Conditions:
with trifluoroacetic acid at 80;Reflux;
Steps:
4.1.4. General procedure C for the synthesis of compounds f1-35
General procedure: Trifluoroacetic acid (4 mL) was added to a mixture of nitrile(1.0 mmol) and thiosemicarbazide (1.1 mmol). The reaction mixturewas stirred and refluxed for 6 h. Then, it was cooled to roomtemperature and aqueous ammonia was added. The precipitatedsolidwas filtered,washed with hot water and air-dried. It should benoted that the compounds f1-f35 were directly used for the nextreaction without further purification.
References:
Xue, Wenjie;Li, Xueyao;Ma, Guixing;Zhang, Hongmin;Chen, Ya;Kirchmair, Johannes;Xia, Jie;Wu, Song [European Journal of Medicinal Chemistry,2020,vol. 188,art. no. 112022]
