5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile synthesis
- Product Name:5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
- CAS Number:1240948-77-9
- Molecular formula:C11H7FN2
- Molecular Weight:186.19
1240948-72-4
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Yield:1240948-77-9 98%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20;
Steps:
4 Preparation of 5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile (Intermediate V-1)
2 g of the intermediate IV-1 was dissolved in 40 ml of methanol, 200 mg of 10% palladium on carbon was added, hydrogen gas was introduced, and the reaction was stirred at room temperature overnight. After the reaction was completed, it was suction filtered with a celite funnel containing celite, and the filtrate was concentrated to give compound of formula V-1, 1.65 g of white solid, yield 98%
References:
CN108558831,2018,A Location in patent:Paragraph 0156-0159
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881674-56-2
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$6.00/250mg
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